(Dates in italics indicate de facto continuation of office)
| Term | Incumbent | Notes |
| French Suzerainty | ||
| 25 July 1798 to 22 August 1799 | Napoléon Bonaparte, Military Commander | |
| 22 August 1799 to 14 June 1800 | Jean Baptiste Kléber, Military Commander | Assassinated |
| 14 June 1800 to 27 June 1801 | Abdullah Jacques-François de Boussay, baron de Menou, Military Commander | Converted to Islam during his tenure |
| British Suzerainty | ||
| 8 March 1801 to 21 March 1801 | Sir Ralph Abercromby, Military Commander | |
| 21 March 1801 to October 1801 | John Hely Hutchinson, Military Commander | Raised to the peerage as Lord Hutchinson during his tenure |
| October 1801 to July 1802 | Richard Lambart, 7th Earl of Cavan, Military Commander | |
| July 1802 to 16 March 1803 | Sir John Stewart, Military Commander | |
| March 1803 to 1807 | Ernest Missett, Resident | |
| 1807 to 1878 | Ottoman Egypt | |
| 1878 to 1879 | Sir Evelyn Baring, Controller-General | |
| 1879 to 15 September 1882 | Sir Edward Baldwin Malet, Controller-General | |
| British-Occupied Egypt | ||
| 15 September 1882 to 11 September 1883 | Sir Edward Baldwin Malet, Controller-General | |
| 11 September 1883 to 6 May 1907 | Sir Evelyn Baring, Consul-General | Raised to the peearge as, successively, Lord Cromer in 1892, Viscount Cromer in 1899 and Earl of Cromer in 1901 |
| 16 May 1907 to 12 July 1911 | Sir John Eldon Gorst, Consul-General | |
| 29 July 1911 to 18 December 1914 | Herbert Horatio Kitchener, 1st Viscount Kitchener, Consul-General | |
| 18 December 1914 to 9 January 1915 | Sir Milne Cheetham, acting High Commissioner | |
| 9 January 1915 to 1 January 1917 | Sir Arthur Henry McMahon, High Commissioner | |
| 1 January 1917 to 7 October 1919 | Sir Francis Reginald Wingate, High Commissioner | |
| 7 October 1919 to 28 February 1922 | Edward Henry Hynman Allenby 1st Viscount Allenby, High Commissioner | |
| Kingdom of Egypt | ||
| 28 February 1922 to 26 May 1925 | Edward Henry Hynman Allenby 1st Viscount Allenby, High Commissioner | |
| 26 May 1925 to 8 August 1929 | Sir George Ambrose Lloyd High Commissioner | Raised to the peerage as Lord Lloyd on 16 November 1925 |
| 8 August 1929 to 16 December 1933 | Sir Percy Lyham Loraine, High Commissioner | |
| 8 January 1934 to 14 November 1936 | Sir Miles Wedderburn Lampson, High Commissioner | |